For the most part spyware is not too hard to get rid of. There are a few of them that are really hard to get rid of and you may have to format and start over. Did you check out our spyware page for help? There are many free tools you can use to remove spyware from your computer.
Be sure to check your startup items too (MSconfig) to make sure there is nothing that seems out of place. Its better to do the spyware scans in Safe Mode as well. Make sure you update the spyware programs running them as well.
You should also check your Programs and Features too see if there are any items in there that don't belong and remove them as well.