I would first check in Device Manager to see if you have any yellow question marks or exclamation marks on your DVD/CD-ROM drives section. If so then I would right click your drive and choose uninstall and then reboot your computer. Windows should recognize it again and reinstall it and hopefully clear up any resource conflicts it may have been having. This is assuming this is not what you meant by uninstalling the drive.
You can also use regedit to edit the registry and try this. Be careful when editing the registry since one wrong move can render your computer inoperable. Click on Start, Run then type regedit and click Ok. Go to File then Export and export your registry to your computer in case you have to restore it. Then browse to the following key.
See if you have a key in your registry for upperfilters and lowerfilters and delete both of these keys and reboot.
You may also want to put the drive on a different controller on the motherboard to see if it makes a difference.